Fibrin glue is a quick and effective treatment for primary and recurrent pilonidal sinus disease

T S Sian1,2, P J J Herrod3,4, J E M Blackwell3,4

  • 1Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Derby, UK. t.sian@nhs.net.

Insights

Fibrin glue obliteration is an effective treatment for pilonidal sinus disease (PSD), offering a quick procedure with high healing rates after two rounds of treatment. This minimally invasive approach provides a viable alternative to traditional radical surgeries for PSD.

Area of Science:

  • Surgical Innovation
  • Minimally Invasive Procedures
  • Wound Healing

Background:

  • Pilonidal sinus disease (PSD) is a chronic inflammatory condition impacting young males, causing significant health and economic burdens.
  • Traditional surgical interventions for PSD often lead to complications such as pain, prolonged recovery, and poor cosmetic outcomes.

Purpose of the Study:

  • To evaluate the efficacy of fibrin glue as a primary treatment for pilonidal sinus disease (PSD).

Main Methods:

  • Retrospective analysis of 146 patients undergoing curettage and fibrin glue obliteration for PSD between January 2011 and January 2016.
  • Data collection included operative details, recurrence rates, and time to recurrence.

Main Results:

  • 99% of patients were discharged same-day, with a median operative time of 9 minutes.
  • A 27% recurrence rate was observed after one fibrin glue application, with 60% of these successfully retreated.
  • A high healing rate of 96.9% was achieved after two rounds of fibrin glue treatment.

Conclusions:

  • Fibrin glue application after sinus curettage is a rapid and effective treatment for pilonidal sinus disease (PSD).
  • This minimally invasive technique serves as a successful first and second-line therapeutic option for PSD, improving patient outcomes.
Abstract

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.2K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
952
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
487
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
538
ECG Interpretation of Arrhythmias I: Sinus Arrhythmias01:16

ECG Interpretation of Arrhythmias I: Sinus Arrhythmias

Arrhythmias are disturbances in the heart's rhythm that lead to abnormal heartbeats. These irregularities can originate from different parts of the heart and are classified based on their origin and nature.
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
828
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
553