Related Experiment Video
Updated: Feb 2, 2026

Multifocal Electroretinograms
Published on: December 4, 2011
Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal
G Classen1, C Classen2, C Bernasconi3
1Department of Paediatric Neurology, Evangelisches Klinikum Bethel, Bielefeld, Germany.
Abstract:
Long-term treatment of multiple sclerosis with natalizumab (NTZ) carries the risk of a devastating complication in the form of an encephalopathy caused by a reactivation of a latent John Cunningham virus infection (progressive multifocal leucoencephalopathy, PML). Early diagnosis is associated with considerably better prognosis. Quantitative EEG as an objective, rater-independent technique provides high sensitivity (88%) and specificity (82%) for the diagnosis of NTZ-PML. Combination of diagnostic modalities addressing static morphological (brain MRI) as well as functional (EEG) pathologic changes may improve risk management programmes.
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