Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Structure01:55

Bone Structure

51.7K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.7K
Bone Remodeling01:40

Bone Remodeling

40.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.4K
Compact Bone01:27

Compact Bone

16.5K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.5K
Bone Disorders01:29

Bone Disorders

5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K
The Hyoid Bone01:12

The Hyoid Bone

5.0K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
5.0K
Spongy Bone01:09

Spongy Bone

7.9K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improved osteogenesis in rat femur segmental defects treated with human allograft and zinc adjuvants.

Experimental biology and medicine (Maywood, N.J.)·2021
Same author

Naproxen treatment inhibits articular cartilage loss in a rat model of osteoarthritis.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2020
Same author

Zinc as a Therapeutic Agent in Bone Regeneration.

Materials (Basel, Switzerland)·2020
Same author

Common Cell Lines Used to Study Bone Morphogenetic Proteins (BMPs).

Methods in molecular biology (Clifton, N.J.)·2018

Related Experiment Video

Updated: Feb 2, 2026

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

8.0K

Bone Morphogenetic Proteins (BMPs) and Bone Regeneration.

Deboleena Kanjilal1, Jessica Ann Cottrell2

  • 1Rutgers University, Newark, NJ, USA.

Methods in Molecular Biology (Clifton, N.J.)
|November 11, 2018
PubMed
Summary
This summary is machine-generated.

This study reviews animal models for bone regeneration research, focusing on the rat femur defect model for evaluating bone morphogenetic protein-2 (BMP-2) efficacy. It details BMP-2 delivery, dosage, and duration in studies.

Keywords:
BMP-2BMP-2 carriersBoneChondrocytesIn vivoOsteoblastsRat femur defect model

More Related Videos

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.0K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.3K

Related Experiment Videos

Last Updated: Feb 2, 2026

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

8.0K
Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.0K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.3K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Research

Background:

  • Bone regeneration research utilizes various methods to understand the role of bone morphogenetic protein-2 (BMP-2).
  • Animal models are crucial for assessing the efficacy of osteogenic factors in bone healing.
  • The rat femur defect model is a widely adopted preclinical tool.

Purpose of the Study:

  • To review key animal models employed in bone regeneration research.
  • To provide detailed insights into the rat femur defect model.
  • To outline critical parameters for BMP-2 studies, including delivery, dosage, and duration.

Main Methods:

  • Literature review of established animal models for bone regeneration.
  • Detailed description of the rat femur defect model.
  • Compilation of data on BMP-2 delivery systems, dose ranges, and treatment durations.

Main Results:

  • The rat femur defect model is a valuable tool for evaluating BMP-2's osteogenic potential.
  • Specific details on BMP-2 delivery methods, optimal dose ranges, and treatment durations are presented.
  • Comparative analysis of different models highlights the rat femur model's utility.

Conclusions:

  • The rat femur defect model offers a reproducible platform for BMP-2 research.
  • Understanding delivery methods and dosage parameters is essential for successful BMP-2 mediated bone regeneration.
  • This review provides a foundational resource for researchers in the field.