Related Experiment Video
Updated: Feb 2, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Double-Humanized Mouse Model to Study Bone Morphogenetic Protein (BMP) Signaling in Tumor Xenografts
Jenna Newman1,2, Rachel NeMoyer3, Andrew Zloza1,2
1Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Abstract:
The activation of the bone morphogenic protein (BMP) signaling pathway in cancer cells has been shown to enhance migration and tumor angiogenesis and promote survival. The BMP signaling pathway regulates benign cells in the tumor microenvironment and is a known regulator of immune cells. The development of BMP receptor inhibitors has allowed the study of tumor xenografts in mice. We describe a double-humanized mouse model with adoptively transferred human immune and human tumor cells that can be used to assess the effects of BMP inhibitors on these human cells in vivo.
More Related Videos
Related Concept Videos
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Fixing Double-strand Breaks
Small-signal Diode Model
Yeast Signaling
Endocrine Signaling
Bacterial Signaling

