Related Experiment Video

Updated: Feb 2, 2026

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification
10:39

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Published on: November 28, 2016

11.8K

Circulating Oxidized Low-Density Lipoprotein is a Strong Risk Factor for the Early Stage of Coronary Heart Disease

Qiang Zhang1, Yongshun Ai2, Huiqiu Dong3

  • 1Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

IUBMB Life
|November 11, 2018
PubMed

Insights

Circulating oxidized low-density lipoprotein (ox-LDL) is elevated in coronary heart disease (CHD). While ox-LDL is a risk factor in early CHD, its levels decrease in advanced stages like unstable angina pectoris and acute myocardial infarction.

Area of Science:

  • Cardiovascular Research
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Coronary heart disease (CHD) involves complex pathological processes.
  • Oxidized low-density lipoprotein (ox-LDL) is implicated in atherosclerosis.
  • Understanding biomarkers for CHD severity is crucial for patient management.

Purpose of the Study:

  • To measure circulating ox-LDL levels in controls and patients with varying CHD severity (stable angina pectoris [SAP], unstable angina pectoris [UAP], acute myocardial infarction [AMI]).
  • To investigate the correlation between ox-LDL and CHD severity.
  • To assess other biomarkers including malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), and lipoprotein (a) (Lp(a)).

Main Methods:

  • Plasma samples from 99 participants undergoing coronary angiography were analyzed.
  • Levels of ox-LDL, MDA, hs-CRP, Lp(a), and lipid profiles were quantified.
  • Statistical analysis was performed to compare groups and assess correlations.

Main Results:

  • Plasma ox-LDL was significantly higher in patients with CHD compared to controls.
  • Ox-LDL levels were lower in UAP and AMI groups than in the SAP group.
  • MDA and hs-CRP were significantly elevated in CHD patients, with MDA and hs-CRP showing significant differences across all groups.
  • Plasma ox-LDL correlated negatively with hs-CRP, while serum MDA correlated positively with hs-CRP in CHD patients.

Conclusions:

  • Circulating ox-LDL is a significant risk factor in the early stages of CHD but not in advanced stages.
  • Elevated MDA and hs-CRP are associated with CHD.
  • Hs-CRP may play a role in the transfer of ox-LDL to macrophages, potentially influencing disease progression.

Keywords:
coronary angiographycoronary heart diseaseoxidized low-density lipoprotein

More Related Videos

High-Density Lipoprotein-Specific Phospholipid Efflux Assay07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

440
Fast and Simplified Method for High Through-put Isolation of miRNA from Highly Purified High Density Lipoprotein09:48

Fast and Simplified Method for High Through-put Isolation of miRNA from Highly Purified High Density Lipoprotein

Published on: July 27, 2016

12.4K

Related Concept Videos

Coronary Circulation01:21

Coronary Circulation

The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.3K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.1K
Strong Acid and Base Solutions03:22

Strong Acid and Base Solutions

A strong acid is a compound that dissociates completely in an aqueous solution and produces a concentration of hydronium ions equal to the initial concentration of acid. For example, 0.20 M hydrobromic acid will dissociate completely in water and produces 0.20 M of hydronium ions and 0.20 M of bromide ions.
35.7K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
451
Titration Calculations: Strong Acid - Strong Base02:28

Titration Calculations: Strong Acid - Strong Base

Calculating pH for Titration Solutions: Strong Acid/Strong Base
A titration is carried out for 25.00 mL of 0.100 M HCl (strong acid) with 0.100 M of a strong base NaOH. The pH at different volumes of added base solution can be calculated as follows:
(a) Titrant volume = 0 mL. The solution pH is due to the acid ionization of HCl. Because this is a strong acid, the ionization is complete and the hydronium ion molarity is 0.100 M. The pH of the solution is then:
33.9K