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Related Concept Videos

Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Feb 2, 2026

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
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An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

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Transluminal Cancer Surgery.

Antonio M Lacy1, Fransisco Borja De Lacy1, Silvia Valverde1

  • 1Department of Gastrointestinal Surgery, ICMDM, IDIBAPS, CIBEREHD, AIS Channel, Hospital Clínic, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain.

Surgical Oncology Clinics of North America
|November 12, 2018
PubMed
Summary
This summary is machine-generated.

Transluminal surgery, or natural orifices endoluminal surgery, offers a highly minimally invasive approach. Procedures like peroral endoscopic myotomy and transanal total mesorectal excision are now safe and feasible for select patients.

Keywords:
Laparoscopic surgeryNatural orifice endoluminal surgeryPeroral endoscopic myotomyTransanal (ta TME)Transluminal cancer surgery

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Area of Science:

  • Surgical Innovation
  • Minimally Invasive Procedures
  • Gastroenterology

Background:

  • Transluminal surgery, also known as natural orifices endoluminal surgery (NOTES), represents a frontier in minimally invasive surgical techniques.
  • While early NOTES procedures like transgastric cholecystectomy faced challenges, significant advancements have been made.

Purpose of the Study:

  • To trace the evolution of transluminal surgery from experimental concepts to established clinical practice.
  • To highlight the development and validation of natural orifices endoluminal surgery (NOTES) techniques.

Main Methods:

  • Review of historical development and clinical application of transluminal surgical approaches.
  • Analysis of the transition from experimental NOTES procedures to validated surgical techniques.

Main Results:

  • Peroral endoscopic myotomy for achalasia and transanal total mesorectal excision for rectal cancer are now accepted, safe, and feasible procedures.
  • Certain NOTES approaches, initially experimental, have matured into reliable surgical options for specific patient groups.

Conclusions:

  • Transluminal surgery has evolved into a validated and effective approach for specific indications.
  • The development of natural orifices endoluminal surgery (NOTES) demonstrates a successful progression from experimental research to clinical acceptance.