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Association Between Maternal Pre-Pregnancy Body Mass Index, Gestational Weight Gain, and Offspring Atopic Dermatitis:

Aaron M Drucker1, Eliza I Pope2, Alison E Field3

  • 1Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Women's College Research Institute and Department of Medicine, Women's College Hospital, Toronto, Ontario, Canada; Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, RI.

The Journal of Allergy and Clinical Immunology. in Practice
|November 12, 2018
PubMed

Insights

Excessive gestational weight gain (GWG) in mothers is linked to a higher risk of atopic dermatitis (AD) in children. Maternal pre-pregnancy body mass index (BMI) did not show a significant association with childhood AD risk.

Area of Science:

  • Pediatric allergy and immunology
  • Maternal and child health
  • Epidemiology of atopic diseases

Background:

  • Maternal weight status is a potential factor in the development of childhood atopic disorders.
  • Understanding the impact of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) is crucial for pediatric health.
  • Atopic dermatitis (AD) is a common childhood condition with complex etiology.

Purpose of the Study:

  • To investigate the association between maternal pre-pregnancy BMI and GWG and the risk of childhood atopic dermatitis (AD).
  • To quantify the risk of AD in offspring based on different categories of maternal GWG and pre-pregnancy BMI.
  • To contribute to the understanding of prenatal influences on allergic disease development.

Main Methods:

  • Prospective cohort study (Growing Up Today Study - GUTS) involving US children.
  • Maternal pre-pregnancy BMI and GWG data collected via questionnaires.
  • Clinician-diagnosed AD in offspring reported retrospectively; analyzed using multivariable logistic regression.

Main Results:

  • A total of 13,269 children were included, with 16% diagnosed with childhood AD.
  • Higher maternal pre-pregnancy BMI was not significantly associated with AD risk.
  • Increased gestational weight gain (GWG) was associated with a higher risk of AD; specifically, GWG of 35-44 lb and ≥45 lb showed increased odds ratios.

Conclusions:

  • Increased gestational weight gain (GWG) is associated with an elevated risk of atopic dermatitis (AD) in children.
  • This finding supports the hypothesis that prenatal exposures, including maternal weight dynamics during pregnancy, play a role in the development of atopic disorders.
  • Further research into maternal health during pregnancy may offer insights into preventing childhood allergies.
Abstract

Keywords:
Atopic dermatitisGestational weight gainMaternal BMIPerinatalPregnancyWeight status

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