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Related Experiment Video

Updated: Feb 2, 2026

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil
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Deep brain stimulation targets for treating depression.

Dominik Drobisz1, Alena Damborská2

  • 1Department of Psychiatry, University Hospital and Masaryk University, Brno, Czech Republic.

Behavioural Brain Research
|November 12, 2018
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Summary

Deep brain stimulation (DBS) offers a promising treatment for treatment-resistant depression (TRD). Research is ongoing to identify optimal DBS targets, as various brain regions show potential for antidepressant effects.

Keywords:
Deep brain stimulationMajor depressive disorderTreatment-resistant depression

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurosurgery

Background:

  • Deep brain stimulation (DBS) is an emerging therapeutic strategy for individuals with treatment-resistant depression (TRD).
  • Preliminary evidence suggests the efficacy and safety of DBS across several brain regions, including the subgenual anterior cingulate cortex and nucleus accumbens.

Purpose of the Study:

  • To provide an updated review of current and potential deep brain stimulation targets for depression.
  • To substantiate the suitability of various DBS targets for treating depression.
  • To discuss the future outlook for DBS in depression treatment.

Main Methods:

  • Literature review of existing studies on DBS for depression.
  • Analysis of preliminary evidence on the efficacy and safety of different DBS targets.
  • Discussion of potential future targets for DBS in depression.

Main Results:

  • Multiple brain regions, including the subgenual anterior cingulate cortex, ventral capsule/striatum, nucleus accumbens, lateral habenula, inferior thalamic peduncle, medial forebrain bundle, and bed nucleus of the stria terminalis, show preliminary efficacy for DBS in TRD.
  • Optimal stimulation targets for DBS in depression are yet to be definitively determined.
  • Antidepressant effects can be achieved through stimulation of diverse targets.

Conclusions:

  • Deep brain stimulation (DBS) is a viable therapeutic option for treatment-resistant depression (TRD).
  • Further research is needed to optimize DBS target selection for maximal antidepressant efficacy.
  • The flexibility in DBS target selection offers a promising future for treating depression.