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Relationship between cerebral microbleeds and white matter MR hyperintensities in systemic lupus erythematosus: a

Hyunjung Yeoh1, Ji Young Lee2, Young-Jun Lee1

  • 1Department of Radiology, Hanyang University Hospital, Hanyang University College of Medicine, 17 Haengdang-dong, Seongdong-gu, Seoul, 133-792, South Korea.

Neuroradiology
|November 12, 2018
PubMed
Abstract

Insights

Cerebral microbleeds (CMBs) are more common in systemic lupus erythematosus (SLE) patients with white matter hyperintensities (WMH). CMBs and severe WMH may indicate vasculitis in SLE patients.

Area of Science:

  • Neurology
  • Radiology
  • Rheumatology

Background:

  • White matter hyperintensities (WMH) and cerebral microbleeds (CMBs) are markers of small vessel disease and neuroinflammation.
  • Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect the brain.

Purpose of the Study:

  • To investigate the relationship between CMBs and WMH in patients with SLE.
  • To determine if CMBs and WMH can serve as imaging biomarkers in SLE.

Main Methods:

  • Compared SLE patients with WMH to those with normal brain MRI.
  • Assessed CMBs using susceptibility-weighted imaging and quantified WMH volume.
  • Performed subgroup analyses based on WMH type (inflammatory vs. SVD) and presence of CMBs.

Main Results:

  • SLE patients with WMH had more frequent CMBs than those without.
  • WMH volume correlated moderately with CMB grading.
  • Inflammatory WMH lesions were associated with more frequent CMBs and larger WMH volume compared to SVD lesions.

Conclusions:

  • CMBs are associated with large-volume WMH and inflammatory lesions in SLE patients.
  • CMBs and severe WMH may serve as imaging biomarkers for vasculitis in SLE.
Keywords:
Cerebral microbleedsMagnetic resonance imagingSusceptibility weighted imagingSystemic lupus erythematosusWhite matter

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