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CRISPR diagnostics: Underappreciated uses in perinatology
Adam Pan1, Katherine L Kraschel1
1Solomon Center for Health Law & Policy, Yale Law School, United States.
Seminars in Perinatology
|November 13, 2018
Summary
CRISPR diagnostics offer a promising, low-hurdle alternative to CRISPR therapies for hereditary diseases. These advanced diagnostic tools are expected to impact medical practices like perinatal screening sooner than therapeutic applications.
Area of Science:
- Biotechnology
- Molecular Diagnostics
- Genetics
Background:
- CRISPR technology holds immense potential for treating hereditary diseases.
- Translating CRISPR therapeutics into clinical practice faces significant technical, regulatory, and ethical challenges.
- CRISPR's application in diagnostics remains an underappreciated area.
Purpose of the Study:
- To highlight the potential of CRISPR-based diagnostic testing.
- To argue that CRISPR diagnostics will precede CRISPR therapeutics in clinical relevance.
- To draw attention to the advantages of CRISPR diagnostics for the medical community.
Main Methods:
- Review of current CRISPR technology applications.
- Analysis of technical, regulatory, and ethical considerations for CRISPR therapeutics versus diagnostics.
- Discussion of potential impact on diagnostic practices, including perinatal screening.
Main Results:
- CRISPR diagnostics are positioned to significantly alter diagnostic methodologies.
- CRISPR diagnostics present fewer technical, regulatory, and ethical barriers compared to CRISPR therapeutics.
- CRISPR diagnostics are likely to achieve clinical relevance before CRISPR-based therapies.
Conclusions:
- CRISPR diagnostics represent a near-term, impactful application of CRISPR technology.
- The medical community should recognize and prepare for the advent of CRISPR-based diagnostics.
- CRISPR diagnostics offer a viable pathway for leveraging CRISPR innovation in healthcare.
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