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Hypofractionated Concomitant Chemoradiation in Inoperable Locally Advanced Non-small Cell Lung Cancer: A Report on
M S Iqbal1, G Vashisht2, R McMenemin1
1Department of Clinical Oncology, Northern Centre for Cancer Care, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Clinical Oncology (Royal College of Radiologists (Great Britain))
|November 13, 2018
Summary
Hypofractionated chemoradiation for inoperable non-small cell lung cancer shows improved survival and treatment completion rates. This regimen offers an effective option with acceptable toxicity for advanced lung cancer patients.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Oncology
Background:
- Concomitant chemoradiation is standard for inoperable non-small cell lung cancer (NSCLC).
- Hypofractionated regimens offer potential benefits in treatment delivery and patient outcomes.
Purpose of the Study:
- To analyze survival outcomes and toxicity data for hypofractionated chemoradiation in NSCLC.
- To compare findings with existing literature and phase II trial data.
Main Methods:
- Retrospective analysis of 100 patients treated with 55 Gy in 20 fractions concurrent with cisplatin vinorelbine chemotherapy.
- Survival estimation using Kaplan-Meier and Cox regression.
- Systematic literature search of Medline, Embase, and Cochrane databases.
Main Results:
- High treatment completion rates: 97% for radiotherapy, 73% for chemotherapy.
- Two-year progression-free survival (PFS) and overall survival (OS) were 49% and 58%.
- Median PFS and OS were 23.4 and 43.4 months, respectively; chemotherapy cycles received was a significant prognostic factor (P=0.02).
Conclusions:
- Hypofractionated chemoradiation demonstrated improved treatment completion and survival with acceptable toxicity compared to prior studies.
- This regimen is an effective option for locally advanced NSCLC with appropriate patient selection.
- The study provides benchmarks for efficacy and toxicity, informing future trial designs incorporating novel agents.
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