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Extracellular Vesicles: Potential Participants in Circadian Rhythm Synchronization
Shi-Cong Tao1, Shang-Chun Guo2
1Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.
International Journal of Biological Sciences
|November 13, 2018
Summary
Circadian rhythms (CRs) maintain health by synchronizing internal clocks. This review explores how extracellular vesicles (EVs) may bridge the gap between the master "server clock" and cellular "client clocks."
Area of Science:
- Chronobiology
- Cellular Biology
- Molecular Biology
Background:
- Circadian rhythms (CRs) are endogenous biological oscillators crucial for maintaining homeostasis and health.
- The synchronization of the master hypothalamic clock ('server clock') with peripheral cellular clocks ('client clocks') remains incompletely understood.
- Transcriptional-translational negative-feedback loops (TTFLs) form the basis of cellular circadian clocks.
Purpose of the Study:
- To review current knowledge on circadian rhythms, TTFLs, and extracellular vesicles (EVs).
- To examine the role of EVs in regulating the CR system and intercellular communication.
- To identify key questions and future research directions regarding EVs in circadian biology.
Main Methods:
- Literature review synthesizing existing research on circadian rhythms, TTFLs, and EVs.
- Analysis of studies investigating the function of EVs in the context of the circadian system.
- Discussion of theoretical models and experimental evidence.
Main Results:
- Extracellular vesicles (EVs) are implicated in intercellular communication and have emerged as potential regulators of cellular 'client clocks'.
- EVs may play a critical role in synchronizing peripheral circadian clocks with the central 'server clock'.
- Current theories struggle to fully explain the synchronization mechanism between the master and peripheral clocks.
Conclusions:
- Extracellular vesicles (EVs) present a promising mechanism for explaining the synchronization of peripheral circadian clocks.
- Further research is needed to elucidate the precise functions and mechanisms of EVs in circadian regulation.
- Understanding the role of EVs in circadian biology could lead to new therapeutic strategies for CR-related disorders.
Keywords:
circadian rhythmsexosomesextracellular vesiclesnoncoding RNAspost-translational modificationstranscriptional-translational negative-feedback loopsMore Related Videos
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