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Updated: Feb 2, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase
Eungi Choi1,1, Jayapal Reddy Mallareddy1,1, Dai Lu2,2
1Department of Biopharmaceutical Sciences, Keck Graduate Institute School of Pharmacy, 535, Watson Dr, Claremont, CA 91711, USA.
Abstract:
AIDS caused by the infection of HIV is a prevalent problem today. Rapid development of drug resistance to existing drug classes has called for the discovery of new targets. Within the three major enzymes (i.e., HIV-1 protease, HIV-1 reverse transcriptase and HIV-1 integrase [IN]) of the viral replication cycle, HIV-1 IN has been of particular interest due to the absence of human cellular homolog. HIV-1 IN catalyzes the integration of viral genetic material with the host genome, a key step in the viral replication process. Several novel classes of HIV IN inhibitors have been explored by targeting different sites on the enzyme. This review strives to provide readers with updates on the recent developments of HIV-1 IN inhibitors.
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