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BRMS1 coordinates with LSD1 and suppresses breast cancer cell metastasis

Rongfang Qiu1, Hang Shi1, Shuang Wang1

  • 12011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University Tianjin 300070, China.

American Journal of Cancer Research
|November 13, 2018
PubMed

Insights

Breast carcinoma metastasis suppressor gene 1 (BRMS1) inhibits metastasis by forming a complex with LSD1. This complex suppresses genes involved in breast cancer cell migration and invasion, offering a therapeutic target.

Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Regulation

Background:

  • Breast carcinoma metastasis suppressor gene 1 (BRMS1) is known to inhibit tumor metastasis.
  • The precise molecular mechanisms underlying BRMS1's role in suppressing breast cancer metastasis, particularly at the transcriptional level, remain largely unelucidated.

Purpose of the Study:

  • To elucidate the mechanism by which BRMS1 suppresses breast cancer metastasis.
  • To identify the protein complex BRMS1 interacts with and its downstream transcriptional targets.

Main Methods:

  • Affinity purification coupled with mass spectrometry (MS) to identify BRMS1 interacting proteins.
  • High-throughput RNA deep sequencing (RNA-seq) to analyze gene expression changes upon BRMS1 complex formation.
  • Functional assays to assess cell migration and invasion.

Main Results:

  • BRMS1 was identified as a component of the LSD1/CoREST corepressor complex.
  • RNA-seq analysis revealed that the BRMS1/LSD1 complex regulates a set of target genes, including metastasis-related genes like VIM, INSIG2, and COL5A2.
  • BRMS1 and LSD1 are collectively essential for inhibiting breast cancer cell migration and invasion.

Conclusions:

  • BRMS1 suppresses breast cancer metastasis through transcriptional regulation mediated by its association with the LSD1/CoREST complex.
  • Targeting the BRMS1-LSD1 interaction presents a potential therapeutic strategy for breast cancer treatment.
Keywords:
BRMS1LSD1Vimentinbreast cancermetastasis

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