A Case Of Recurrent Helicobacter cinaedi Prosthetic Joint Infection In An HIV-Infected Man

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Joanna Kedra1, Valérie Zeller2, Beate Heym3

  • 1Service de Médecine Interne et Rhumatologie, Groupe Hospitalier Diaconesses-Croix Saint-Simon, 125, rue d'Avron, 75020 Paris, France.

Journal of Bone and Joint Infection
|November 13, 2018
PubMed

Insights

This is the first reported case of recurrent prosthetic joint infection caused by Helicobacter cinaedi in an HIV-infected patient. The study highlights the bacterium

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Orthopedics

Background:

  • HIV infection compromises the immune system, increasing susceptibility to opportunistic infections.
  • Prosthetic joint infections (PJIs) are serious complications following joint replacement surgery.
  • Helicobacter cinaedi is an emerging pathogen, rarely associated with PJI.

Purpose of the Study:

  • To report the first case of recurrent PJI caused by Helicobacter cinaedi in an immunocompromised patient.
  • To emphasize the diagnostic challenges and treatment complexities associated with Helicobacter cinaedi infections.

Main Methods:

  • Case report of an HIV-infected patient with recurrent PJI.
  • Clinical presentation, microbiological investigations, and treatment course were documented.
  • Literature review on Helicobacter cinaedi infections and PJIs.

Main Results:

  • The patient experienced two episodes of PJI with Helicobacter cinaedi despite appropriate antibiotic therapy.
  • Helicobacter cinaedi proved difficult to isolate from clinical samples.
  • Recurrence of infection occurred even after seemingly successful treatment, indicating potential for persistent or relapsing infections.

Conclusions:

  • Recurrent prosthetic joint infection by Helicobacter cinaedi is possible, even in HIV-infected individuals.
  • Early and accurate diagnosis of Helicobacter cinaedi is crucial but challenging.
  • Management of such infections may require prolonged or multi-faceted treatment strategies.
Keywords:
Helicobacter cinaediprosthetic joint infectionrecurrence

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