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Ferret badger rabies in Zhejiang, Jiangxi and Taiwan, China
Jing-Hui Zhao1,2,3,4, Li-Feng Zhao5, Fei Liu6
1School of Animal Science and Technology, Changchun University of Science and Technology, Changchun, 130600, China. zhaojinghui8791@hotmail.com.
Abstract:
Ferret badger (FB, Melogale moschata) rabies is an increasing public health threat to humans, with FBs being a major reservoir and vector of rabies in China. Based on 152 published nucleotide sequences of the FB rabies virus (RABV) nucleoprotein, phylogenetic analysis revealed them to be clustered into six FB-related lineages, FB-I to FB-VI. The genetic features of members of lineage FB-VI suggest that cross-species transmission occurs between FBs and dogs. Here, we describe the phylogenetic relationships between FB-RABVs, their geographic segregation, and their evolutionary dynamics in epizootic regions.
Insights
Ferret badger rabies virus (RABV) in China poses a growing threat. Phylogenetic analysis identified six lineages, with one suggesting rabies transmission between ferret badgers and dogs.
Area of Science:
- Veterinary Virology
- Public Health
- Molecular Epidemiology
Background:
- Ferret badger (FB) rabies virus (RABV) is a significant public health concern in China.
- Ferret badgers are a primary reservoir and vector for RABV.
- Understanding FB-RABV evolution is crucial for disease control.
Purpose of the Study:
- To analyze the phylogenetic relationships of FB-RABVs.
- To investigate the geographic distribution and evolutionary dynamics of FB-RABV.
- To identify potential cross-species transmission events.
Main Methods:
- Phylogenetic analysis of 152 published FB-RABV nucleoprotein nucleotide sequences.
- Examination of genetic features within identified lineages.
- Mapping of geographic segregation and evolutionary trends.
Main Results:
- FB-RABVs clustered into six distinct lineages (FB-I to FB-VI).
- Lineage FB-VI exhibits genetic characteristics indicative of cross-species transmission between ferret badgers and dogs.
- Distinct geographic segregation and evolutionary dynamics were observed.
Conclusions:
- FB-RABV populations are genetically diverse and geographically structured.
- Cross-species transmission, particularly involving dogs, is a key factor in FB-RABV epidemiology.
- Further research into FB-RABV transmission dynamics is warranted for effective public health interventions.
