Related Experiment Video

Updated: Feb 2, 2026

Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice
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Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice

Published on: April 15, 2014

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Persistent MOG-IgG positivity is a predictor of recurrence in MOG-IgG-associated optic neuritis, encephalitis and

Luana Michelli Oliveira1, Samira Luisa Apóstolos-Pereira1, Milena Sales Pitombeira1

  • 1Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, Brazil.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|November 13, 2018
PubMed
Abstract

Insights

In MOG-IgG-associated disorders, persistent positive MOG-IgG serostatus predicts relapses, while a monophasic course leads to spontaneous seronegativity. This helps understand disease activity in MOG-IgG patients.

Area of Science:

  • Neuroimmunology
  • Central Nervous System (CNS) Inflammatory Disorders

Background:

  • MOG-IgG-associated optic neuritis, encephalitis, and myelitis (MONEM) are distinct CNS inflammatory disorders.
  • MONEM differs from multiple sclerosis and neuromyelitis optica spectrum disorders.
  • Predictors of relapse in MONEM are not well-established.

Purpose of the Study:

  • To assess longitudinal MOG-IgG serostatus in patients.
  • To correlate MOG-IgG serostatus with long-term clinical outcomes.

Main Methods:

  • Retrospective study of 31 MOG-IgG-positive patients with demyelinating CNS disorders.
  • Follow-up data collected from 2011 to 2017 at the University of São Paulo, Brazil.

Main Results:

  • 74% of patients experienced relapsing disease; 26% had a monophasic course.
  • Monophasic patients and most relapsing patients became MOG-IgG seronegative during remission.
  • Persistent MOG-IgG positivity, especially with higher titers, correlated with recent disease activity.

Conclusions:

  • MOG-IgG patients typically have a relapsing course.
  • Persistent MOG-IgG seropositivity is linked to increased relapse risk.
  • Spontaneous MOG-IgG seronegativity occurs in patients with a single attack.
Keywords:
Immunoglobulin G (IgG) antibodies to myelin oligodendrocyte glycoproteinMOG-IgG associated with optic neuritiscell-based assayencephalitis and myelitislongitudinally extensive transverse myelitisneuromyelitis opticaoptic neuritis

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