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Bacteriostatic and Bactericidal Activity of Deer Musk on Multidrug Resistance Bacteria

Ashwag Yosef Shami, Abdulhadi Almasri

    Pakistan Journal of Biological Sciences : PJBS
    |November 13, 2018
    PubMed
    Abstract

    Insights

    Deer musk exhibits antimicrobial activity against multidrug-resistant bacteria, demonstrating both bacteriostatic and bactericidal effects. This natural substance shows promise in combating resistant infections.

    Area of Science:

    • Microbiology
    • Pharmacology
    • Natural Products Chemistry

    Background:

    • Multidrug resistance (MDR) in bacterial pathogens poses a significant global health threat, leading to increased morbidity and mortality.
    • The emergence of resistance necessitates the exploration of novel antimicrobial agents.
    • Deer musk is a traditional substance with potential medicinal properties.

    Purpose of the Study:

    • To investigate the antimicrobial activity of deer musk against multidrug-resistant (MDR) bacteria.
    • To determine if deer musk possesses bacteriostatic and bactericidal effects on MDR bacterial strains.
    • To evaluate the impact of deer musk on bacterial cell morphology.

    Main Methods:

    • Eleven MDR bacterial species were tested, including Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
    • Antimicrobial activity was assessed using disk diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) assays.
    • Bacterial susceptibility to common antimicrobials was also evaluated for comparison.

    Main Results:

    • Deer musk demonstrated bacteriostatic and bactericidal activity against all tested MDR strains, with MIC and MBC values <2% (v/v) for most strains.
    • Activity against Pseudomonas aeruginosa was observed at >2% (v/v).
    • Morphological changes in bacterial colonies of Staphylococcus aureus, Streptococcus agalactiae, Pseudomonas aeruginosa, and Klebsiella pneumoniae suggest an effect on bacterial cell membranes.

    Conclusions:

    • Deer musk exhibits significant bacteriostatic and bactericidal effects against a range of MDR bacteria.
    • The findings support the potential of deer musk as a source for developing new antimicrobial strategies.
    • Deer musk's impact on bacterial cell membranes warrants further investigation.
    Keywords:
    Muskantimicrobial drugantimicrobial susceptibilityinfecting agentminimum bactericidal concentrationminimum inhibitory concentrationmultidrug resistance

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