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The International Multiple Sclerosis Visual System Consortium: Advancing Visual System Research in Multiple

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The International Multiple Sclerosis Visual System Consortium (IMSVISUAL) advances multiple sclerosis (MS) research by focusing on visual system changes. Their work establishes optical coherence tomography (OCT) as a predictor of MS disability and guides future research.

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Area of Science:

  • Ophthalmology
  • Neurology
  • Medical Research

Background:

  • The International Multiple Sclerosis Visual System Consortium (IMSVISUAL) was established in 2014.
  • Its primary goal is to enhance research, care, and education concerning the visual system in multiple sclerosis (MS).

Purpose of the Study:

  • To detail the formation, objectives, activities, and structure of IMSVISUAL.
  • To outline IMSVISUAL's relationship with the Americas Committee for Treatment and Research in MS (ACTRIMS).
  • To present completed and ongoing research projects within IMSVISUAL.

Main Methods:

  • Describing the formation, goals, activities, and structure of IMSVISUAL.
  • Reviewing the relationship between IMSVISUAL and ACTRIMS.
  • Summarizing completed and ongoing IMSVISUAL research projects.

Main Results:

  • IMSVISUAL has 140 global members and is expanding.
  • Research shows optical coherence tomography (OCT)-derived peripapillary retinal nerve fiber layer (pRNFL) thinning predicts future MS disability.
  • Systematic review indicates reduced pRNFL and ganglion cell + inner plexiform layer (GCIPL) thicknesses in MS patients, especially with prior optic neuritis (ON).

Conclusions:

  • IMSVISUAL signifies a collaborative commitment to defining the role of visual outcomes in MS research.
  • The consortium has completed international projects and is engaged in ongoing studies.
  • IMSVISUAL aims to expand vision research's role in MS and related disorders.