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Association of High-Sensitivity Troponin T With Left Ventricular Dysfunction in Ankylosing Spondylitis

Serdar Turkmen1, Lutfu Askin1, Kader Eliz Uzel1

  • 1From the Departments of Cardiology.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|November 13, 2018
PubMed

Insights

Ankylosing spondylitis patients show impaired left ventricular function and elevated high-sensitivity cardiac troponin T (hs-cTnT) levels. hs-cTnT may predict diastolic dysfunction in these patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Biomarkers

Background:

  • Ankylosing spondylitis (AS) is a systemic inflammatory disease.
  • Cardiac dysfunction in AS is not well-characterized.
  • High-sensitivity cardiac troponin T (hs-cTnT) indicates subclinical myocardial injury.

Purpose of the Study:

  • To investigate the relationship between hs-cTnT and left ventricular (LV) function in AS patients.
  • To assess LV function using tissue Doppler imaging (TDI) in AS patients without known cardiac risk factors.

Main Methods:

  • Cross-sectional study comparing 40 AS patients with age- and sex-matched healthy controls.
  • Transthoracic echocardiography with TDI to evaluate LV systolic and diastolic function.
  • Measurement of hs-cTnT levels and comparison between groups.

Main Results:

  • AS patients exhibited reduced early/late diastolic velocities, mitral annular plane systolic excursion, and LV end-diastolic distance.
  • AS patients showed increased systolic myocardial velocity, isovolumetric relaxation time, and displacement index.
  • Elevated hs-cTnT levels were found in AS patients, predicting LV diastolic dysfunction.

Conclusions:

  • AS patients demonstrate impaired LV function and elevated hs-cTnT.
  • TDI is valuable for detecting early LV abnormalities in AS.
  • hs-cTnT serves as a potential biomarker for diastolic LV dysfunction in AS.
Abstract

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