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Compromised Growth Among HIV-exposed Uninfected Compared With Unexposed Children in Nigeria

Jibreel Jumare1, Pam Datong2,3, Sophia Osawe2,4

  • 1From the Division of Epidemiology and Prevention, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD.

The Pediatric Infectious Disease Journal
|November 13, 2018
PubMed

Insights

HIV-exposed but uninfected (HEU) children in Nigeria showed significantly impaired growth compared to HIV-unexposed but uninfected (HUU) children. HEU infants faced higher risks of stunting and being underweight during their first 18 months.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Global Health

Background:

  • HIV-exposed but uninfected (HEU) children may experience growth impairments.
  • Comparison with HIV-unexposed and uninfected (HUU) children is crucial for understanding HEU health outcomes.

Purpose of the Study:

  • To compare the growth patterns of HEU children with HUU children in Nigeria.
  • To identify potential growth disparities in HEU infants during the first 18 months of life.

Main Methods:

  • Longitudinal study of mother-infant pairs in Nigeria.
  • Anthropometric measurements (weight, length, head circumference) collected over 18 months.
  • WHO Child Growth Standards used to calculate Z scores for stunting, underweight, and wasting.

Main Results:

  • Higher odds of stunting (aOR: 2.4) and underweight (aOR: 1.6) were observed in HEU children compared to HUU children.
  • Prevalence of stunting, underweight, and wasting at birth was noted in both groups, with HEU children showing higher risks.

Conclusions:

  • HEU children in Nigeria exhibit more impaired linear and ponderal growth than HUU children in the first 18 months.
  • Further research is necessary to elucidate the underlying causes of these growth differences.
Abstract

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