Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human cerebral malaria.

M Aikawa1

  • 1Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.

The American Journal of Tropical Medicine and Hygiene
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

Cerebral malaria is primarily caused by Plasmodium falciparum infected red blood cells blocking brain capillaries. These infected cells have knobs that adhere to blood vessel walls, leading to severe pathology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Production cross sections of Mo, Nb and Zr radioisotopes from α-induced reaction on <sup>nat</sup>Zr.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2018
Same author

Measurement of activation cross sections of alpha particle induced reactions on iridium up to an energy of 50 MeV.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2018
Same author

Production cross sections of <sup>169</sup>Yb and Tm isotopes in deuteron-induced reactions on <sup>169</sup>Tm.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2017
Same author

Cross section measurement of alpha particle induced nuclear reactions on natural cadmium up to 52MeV.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2016
Same author

Cysteine Protease Inhibitors Produced by the Industrial Koji Mold, Aspergillus oryzae O-1018.

Bioscience, biotechnology, and biochemistry·2016
Same author

Development of novel treatment with a bioabsorbable esophageal patch for benign esophageal stricture.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2014
Same journal

Use of a Gamification Platform to Teach Tropical Medicine: A Pilot Study.

The American journal of tropical medicine and hygiene·2026
Same journal

The Proposed United States Office of Management and Budget Rule for Managing Biomedical Research Grants and Cooperative Agreements Needs to Change.

The American journal of tropical medicine and hygiene·2026
Same journal

Retiform Purpura Due to Microvascular Occlusion: An Archetypical Manifestation of Lucio Phenomenon in Lepromatous Leprosy.

The American journal of tropical medicine and hygiene·2026
Same journal

Nineteenth-Century British West Indies Soldiers Were Not Intrinsically Resistant to Disease Mortality in West Africa.

The American journal of tropical medicine and hygiene·2026
Same journal

Scrub Typhus Presenting with Isolated Xerostomia.

The American journal of tropical medicine and hygiene·2026
Same journal

Prevalence and Cytopathological Patterns of Tuberculous Lymphadenitis at a Tertiary Hospital in Eastern Ethiopia.

The American journal of tropical medicine and hygiene·2026
See all related articles

Area of Science:

  • Pathology
  • Immunology
  • Infectious Diseases

Background:

  • Cerebral malaria is a severe complication of Plasmodium falciparum infection.
  • Understanding its pathogenesis is crucial for developing effective treatments and preventative strategies.

Purpose of the Study:

  • To investigate the pathological factors contributing to cerebral malaria development.
  • To elucidate the role of infected erythrocyte adhesion and immunological responses in cerebral malaria.

Main Methods:

  • Pathological examination of brain tissue from Burmese patients deceased from cerebral malaria.
  • Electron microscopy to analyze the ultrastructure of infected erythrocytes and their interaction with endothelial cells.
  • Immunohistochemical analysis to detect Plasmodium falciparum antigens and host immune molecules.

Related Experiment Videos

Main Results:

  • Blockage of cerebral capillaries by Plasmodium falciparum infected erythrocytes is the principal cause of cerebral malaria.
  • Knobs on infected erythrocytes mediate adhesion to endothelial cells, contributing to capillary lumen blockage.
  • Presence of IgG, IgM, P. falciparum antigens, and knob proteins in cerebral capillaries suggests an immunological role.

Conclusions:

  • Adhesion of infected erythrocytes, mediated by knobs, is a key mechanism in cerebral malaria pathogenesis.
  • Immunological factors may also contribute to the development of cerebral malaria.
  • Future malaria vaccines should be evaluated for their impact on infected erythrocyte sequestration in the brain.