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[Hemodynamics in donor plasmapheresis].

B von Bormann1, J Boldt, W Schleinzer

  • 1Abteilung Anaesthesiologie und operative Intensivmedizin, Justus-Liebig-Universität Giessen.

Der Anaesthesist
|May 1, 1988
PubMed
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Preoperative autologous plasma collection via donor plasmapheresis shows no significant hemodynamic impact in patients undergoing coronary bypass surgery. This blood conservation technique is safe for surgical candidates.

Area of Science:

  • Cardiovascular Surgery
  • Transfusion Medicine
  • Anesthesiology

Background:

  • Autologous plasma collection via plasmapheresis is a blood conservation strategy for elective surgeries.
  • Preoperative plasma withdrawal aims to reduce the need for allogeneic blood transfusions.
  • The hemodynamic effects of this procedure require thorough investigation.

Purpose of the Study:

  • To evaluate the hemodynamic effects of donor plasmapheresis in patients scheduled for coronary bypass surgery.
  • To assess the safety and impact of autologous plasma withdrawal on cardiovascular function before surgery.

Main Methods:

  • Thirty patients undergoing coronary bypass surgery were divided into two groups: 15 underwent plasmapheresis, and 15 served as controls.
  • Plasmapheresis involved withdrawing 10 ml plasma/kg body weight using a one-needle technique before anesthesia.

Related Experiment Videos

  • Hemodynamic parameters including heart rate, blood pressure, atrial pressures, vascular resistance, and cardiac output were monitored.

    • Main Results:

    • No significant changes in heart rate, arterial blood pressure, or vascular resistance were observed post-plasmapheresis.
    • Preload, afterload, and cardiac index remained stable in the plasmapheresis group compared to the control group.
    • The procedure did not induce any clinically relevant adverse hemodynamic effects.

    Conclusions:

    • Preoperative donor plasmapheresis is hemodynamically safe for patients undergoing coronary bypass surgery.
    • Autologous plasma collection does not negatively impact cardiovascular function in this patient population.
    • This blood conservation method can be safely employed without compromising patient stability.