Palladium-Catalyzed Intermolecular Dehydrogenative Carboamination of Alkenes with Amines and N-Substituted Isatin
Kemant Pratap1,2, Atul Kumar1,2
1Medicinal and Process Chemistry Division , CSIR-Central Drug Research Institute , Sector 10, Jankipuram Extension , Lucknow - 226031 , India.
Abstract:
The first intermolecular dehydrogenative carboamination of alkenes with aromatic amines and N-substituted isatin has been developed using palladium as a catalyst. This multicomponent reaction is a valuable synthetic tool for difunctionalization of the alkene with retention of the C-C double bond. This reaction has two very distinguishing features: (1) the formation of the C-N and C-C bonds with retention of the double bond and (2) high regioselectivity. Thus, this strategy has opened up a new area in chemistry.
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