Related Experiment Video
Updated: Feb 2, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
Published on: June 5, 2020
Dynamical analysis for a hepatitis B transmission model with immigration and infection age
Suxia Zhang1, Hongbin Guo, Robert Smith
1School of Science, Xi'an University of Technology, Xi'an 710048, China.
Abstract:
Hepatitis B virus (HBV) is responsible for an estimated 378 million infections worldwide and 620, 000 deaths annually. Safe and effective vaccination programs have been available for decades, but coverage is limited due to economic and social factors. We investigate the effect of immigration and infection age on HBV transmission dynamics, incorporating age-dependent immigration flow and vertical transmission. The mathematical model can be used to describe HBV transmission in highly endemic regions with vertical transmission and migration of infected HBV individuals. Due to the effects of immigration, there is no disease-free equilibrium or reproduction number. We show that the unique endemic equilibrium exists only when immigration into the infective class is measurable. The smoothness and attractiveness of the solution semiflow are analyzed, and boundedness and uniform persistence are determined. Global stability of the unique endemic equilibrium is shown by a Lyapunov functional for a special case.
More Related Videos
10:40Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
Published on: August 4, 2012
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
Related Concept Videos
Design of Transmission Shafts - Stress Analysis
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Hepatic Portal System
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
The Effect of Aging on Tissues
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
A recent model describes pravastatin's hepatobiliary excretion,...