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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
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NF-kappaB-inducing kinase in cancer
Gunter Maubach1, Michael H Feige1, Michelle C C Lim1
1Institute of Experimental Internal Medicine, Otto von Guericke University, 39120 Magdeburg, Germany.
Biochimica Et Biophysica Acta. Reviews on Cancer
|November 13, 2018
Summary
The NF-κB-inducing kinase (NIK) pathway is crucial in cancer development. Targeting NIK offers a promising therapeutic strategy for various human malignancies, with ongoing research into specific inhibitors.
Area of Science:
- Molecular Biology
- Oncology
- Signal Transduction
Background:
- The alternative NF-κB signaling pathway plays a critical role in development and is implicated in oncogenesis.
- Stabilization of NF-κB-inducing kinase (NIK) is essential for activating this pathway.
Purpose of the Study:
- To review the emerging role of NIK in cancer.
- To highlight NIK as a potential therapeutic target in oncology.
Main Methods:
- Review of recent scientific literature on NIK in cancer.
- Analysis of documented alterations in NIK and its regulatory complex.
- Discussion of NIK activity in human malignancies.
Main Results:
- Dysregulation of NIK is observed in various human cancers.
- Alterations in NIK occur at multiple levels, including transcript, copy number, mutations, and protein modifications.
- High NIK activity correlates with poor patient survival in malignancies.
Conclusions:
- NIK is a significant factor in cancer development and progression.
- NIK represents a viable therapeutic target for cancer treatment.
- Development of specific NIK inhibitors is progressing.
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