Related Experiment Video
Updated: Feb 2, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Immunological therapy: A novel thriving area for triple-negative breast cancer treatment
Xiangyu Wang1, Yihang Qi2, Xiangyi Kong2
1Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China; Department of Laboratory Medicine, Mayo Clinic, Rochester, MN, 55902, USA.
Abstract:
Triple-negative breast cancer (TNBC) refers to cancers that are low in expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). TNBC tends to behave more aggressively than other types of breast cancer. Unlike other breast cancer subtypes (ie, ER-positive, HER2-positive subtypes), there are no approved targeted treatments available, other than the administration of chemotherapy. Immunotherapy is a new kind of treatment approach for TNBC when compared with the surgical treatment, chemotherapy, endocrine therapy, and molecular targeting therapy. The present article reviews the research progresses of immunotherapy for TNBC in recent years. The full text structure covers molecular classification of TNBC, active immunotherapy of TNBC, passive immunotherapy of TNBC, oncolytic immunotherapy and the prospect of immunotherapy for TNBC.
Insights
Triple-negative breast cancer (TNBC) lacks targeted treatments. Immunotherapy offers a promising new avenue for treating this aggressive cancer, with ongoing research into various approaches.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies beyond chemotherapy.
- Existing treatments for TNBC include surgery, chemotherapy, endocrine therapy, and molecular targeting therapy.
- Immunotherapy represents a novel treatment modality for TNBC.
Purpose of the Study:
- To review recent research advancements in immunotherapy for TNBC.
- To provide a comprehensive overview of current and emerging immunotherapy strategies for TNBC.
Main Methods:
- Review of recent scientific literature on TNBC immunotherapy.
- Analysis of different immunotherapy approaches including active, passive, and oncolytic immunotherapy.
- Exploration of TNBC molecular classification relevant to immunotherapy.
Main Results:
- Immunotherapy is an emerging treatment for TNBC, distinct from traditional methods.
- Research covers active, passive, and oncolytic immunotherapy strategies.
- Molecular classification of TNBC is crucial for immunotherapy development.
Conclusions:
- Immunotherapy holds significant promise for advancing TNBC treatment.
- Further research into immunotherapy approaches is essential for clinical application.
- The review highlights the evolving landscape of TNBC therapeutic options.
More Related Videos
Related Concept Videos
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Treatment Resistant Cancers
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Gene Therapy
Scalar and Vector Triple Products
The scalar triple product is the dot product of a vector with the cross product of two vectors....

