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Related Experiment Videos

Serum cholesterol variations in individual patients.

C M Grossman

    Atherosclerosis
    |June 1, 1988
    PubMed
    Summary
    This summary is machine-generated.

    Serum cholesterol levels in patients show significant intra-individual variations, similar to findings in volunteers. Different patient populations exhibit varying cholesterol level variances, necessitating multiple measurements for accurate therapeutic evaluation.

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    Area of Science:

    • Clinical Chemistry
    • Biostatistics
    • Internal Medicine

    Background:

    • Serum cholesterol levels are critical indicators of cardiovascular health.
    • Understanding intra-individual variability is essential for accurate patient assessment.
    • Previous studies documented variability in volunteers, but patient data were less clear.

    Purpose of the Study:

    • To analyze the extent and patterns of intra-individual serum cholesterol level variations in a patient cohort.
    • To compare patient cholesterol variability with existing data from volunteer studies.
    • To provide evidence-based recommendations for clinical practice regarding cholesterol monitoring.

    Main Methods:

    • Retrospective analysis of serum cholesterol measurements.
    • Inclusion of 77 office patients with longitudinal data spanning 1-12 years.

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  • Statistical examination of variance within individual patients over time.

    • Main Results:

    • Confirmed significant intra-individual variations in serum cholesterol levels among patients.
    • Identified distinct patient subgroups with either small or large cholesterol variances.
    • Observed variability in patients mirrored patterns previously reported in volunteer populations.

    Conclusions:

    • Intra-individual cholesterol variability is a significant factor in patient populations.
    • The presence of multiple variance patterns suggests differing physiological responses.
    • Physicians should obtain multiple independent cholesterol measurements to reliably assess therapeutic effectiveness.