Related Experiment Video
Updated: Aug 20, 2026

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
Published on: May 11, 2015
Systemic and intraocular factors related to retinal thicknesses variations in patients with Parkinson's disease
Lorenzo Ferro Desideri1, Fabio Barra2, Simone Ferrero2
1Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Italy.
Abstract:
Parkinson's disease (PD) is characterized by a neurodegenerative process, which has been previously reported to involve some retinal layers, in particular the peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (mGCC). When measuring pRNFL and mGCC by Optical Coherence Tomography in PD patients, it should not be neglected the role of possible both sistemic and intraocular factors, which have been proven to modify intraretinal thicknesses measurements. Nonetheless, also dopaminergic drugs administration could represent another important confounding factor, given their neuroprotective effect exerted on retina.
Related Concept Videos
Photoreceptors and Visual Pathways
Parkinson's Disease: Overview
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Diabetic Retinopathy
Parkinson Disease l: Introduction
Parkinson Disease ll: Pathophysiology

