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Updated: Feb 2, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
Published on: January 7, 2019
Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ
Claudia Carpentier1, Xavier Barbeau2, Jabrane Azelmat3
1Département de Chimie and PROTEO, Université Laval, 1045 avenue de la Médecine, Québec G1V 0A6, Canada.
Abstract:
Herein we report the anti-inflammatory activity of lobaric acid and pseudodepsidones isolated from the nordic lichen Stereocaulon paschale. Lobaric acid (1) and three compounds (2, 7 and 9) were found to inhibit the NF-κB activation and the secretion of pro-inflammatory cytokines (IL-1β and TNF-α) in LPS-stimulated macrophages. Inhibition and docking simulation experiments provided evidence that lobaric acid and pseudodepsidones bind to PPAR-γ between helix H3 and the beta sheet, similarly to partial PPAR-γ agonists. These findings suggest that lobaric acid and pseudodepsidones reduce the expression of pro-inflammatory cytokines by blocking the NF-κB pathway via the activation of PPAR-γ.
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