Related Experiment Video
Updated: Feb 2, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
Reliability of fast magnetic resonance imaging for acute ischemic stroke patients using a 1.5-T scanner
Mi Sun Chung1, Ji Ye Lee2, Seung Chai Jung3
1Department of Radiology, Chung-Ang University Hospital, Seoul, South Korea.
Objectives:
To determine whether fast scanned MRI using a 1.5-T scanner is a reliable method for the detection and characterization of acute ischemic stroke in comparison with conventional MRI.
Methods:
From May 2015 to June 2016, 862 patients (FLAIR, n = 482; GRE, n = 380; MRA, n = 190) were prospectively enrolled in the study, with informed consent and under institutional review board approval. The patients underwent both fast (EPI-FLAIR, ETL-FLAIR, TR-FLAIR, EPI-GRE, parallel-GRE, fast CE-MRA) and conventional MRI (FLAIR, GRE, time-of-flight MRA, fast CE-MRA). Two neuroradiologists independently assessed agreements in acute and chronic ischemic hyperintensity, hyperintense vessels (FLAIR), microbleeds, susceptibility vessel signs, hemorrhagic transformation (GRE), stenosis (MRA), and image quality (all MRI), between fast and conventional MRI. Agreements between fast and conventional MRI were evaluated by generalized estimating equations. Z-scores were used for comparisons of the percentage agreement among fast FLAIR sequences and fast GRE sequences and between conventional and fast MRA.
Results:
Agreements of more than 80% were achieved between fast and conventional MRI (ETL-FLAIR, 96%; TR-FLAIR, 97%; EPI-GRE, 96%; parallel-GRE, 98%; fast CE-MRA, 86%). ETL- and TR-FLAIR were significantly superior to EPI-FLAIR in the detection of acute ischemic hyperintensity and hyperintense vessels, while parallel-GRE was significantly superior to EPI-GRE in the detection of susceptibility vessel sign (p value < 0.05 for all). There were no significant differences in the other scores and image qualities (p value > 0.05).
Conclusions:
Fast MRI at 1.5 T is a reliable method for the detection and characterization of acute ischemic stroke in comparison with conventional MRI.
Key Points:
• Fast MRI at 1.5 T may achieve a high intermethod reliability in the detection and characterization of acute ischemic stroke with a reduction in scan time in comparison with conventional MRI.
Insights
Fast MRI at 1.5 T reliably detects and characterizes acute ischemic stroke, offering a quicker alternative to conventional MRI. This advanced imaging technique shows high agreement with standard methods, improving diagnostic efficiency.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Acute ischemic stroke diagnosis relies on timely and accurate imaging.
- Conventional MRI sequences can be time-consuming, potentially delaying treatment.
- Advancements in MRI technology aim to improve speed and diagnostic yield.
Purpose of the Study:
- To evaluate the reliability of fast-scan MRI at 1.5 Tesla for diagnosing acute ischemic stroke.
- To compare the diagnostic performance of fast MRI sequences against conventional MRI methods.
- To assess the accuracy in detecting and characterizing stroke-related imaging findings.
Main Methods:
- Prospective enrollment of 862 patients undergoing both fast and conventional MRI protocols.
- Utilized various fast sequences including EPI-FLAIR, ETL-FLAIR, TR-FLAIR, EPI-GRE, parallel-GRE, and fast CE-MRA.
- Independent assessment by two neuroradiologists comparing agreements on ischemic hyperintensity, microbleeds, vessel signs, and image quality.
Main Results:
- High agreement (>80%) observed between fast and conventional MRI techniques.
- Specific fast sequences (ETL-FLAIR, TR-FLAIR, parallel-GRE) demonstrated significant superiority in detecting certain stroke indicators.
- No significant differences in overall image quality or other assessed parameters were found between methods.
Conclusions:
- Fast MRI at 1.5 T is a reliable and effective tool for acute ischemic stroke detection and characterization.
- This technique offers potential for reduced scan times without compromising diagnostic accuracy.
- Fast MRI represents a valuable advancement for stroke imaging protocols.
Related Concept Videos
Magnetic Resonance Imaging
Imaging Studies IV: Magnetic Resonance Imaging
Atomic Nuclei: Magnetic Resonance
Reliability and Validity
Nuclear Magnetic Resonance (NMR): Overview
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
Resonance

