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Hereditary clear cell meningiomas in a single family: three-cases report

Takuro Inoue1, Satoshi Shitara2, Michio Ozeki3

  • 1Department of Neurosurgery, Subarukai Kotoh Kinen Hospital, 2-1 Hiramatsu-cho, Higashiohmi-shi, Shiga, 527-0134, Japan. takuro39@gmail.com.

Acta Neurochirurgica
|November 14, 2018
PubMed

Insights

Hereditary clear cell meningiomas (CCMs) were identified in three family members using Sanger sequencing. Early screening of high-risk families is crucial for detecting these rare tumors.

Area of Science:

  • Neuro-oncology
  • Genetics
  • Neurosurgery

Background:

  • Clear cell meningiomas (CCMs) are uncommon tumors requiring surgical resection.
  • Hereditary factors can contribute to meningioma development.

Observation:

  • Three hereditary cases of clear cell meningiomas were identified in a family.
  • Sanger sequencing of lymphocyte DNA confirmed the CCM diagnosis.
  • Tumors were located in the spine and cerebellopontine angle (CPA).

Findings:

  • Gross total resection was successful for spinal CCM in a child and CPA CCM in an adult.
  • Complete resection was not achieved for a large CPA CCM in an adolescent.
  • Genetic analysis confirmed hereditary clear cell meningiomas.

Implications:

  • Early detection through screening is recommended for families with a history of CCM.
  • Understanding the hereditary basis of CCMs may inform future treatment strategies.
  • This case series highlights the importance of genetic evaluation in rare tumor presentations.
Keywords:
Clear cell meningiomaFamilialGene mutationHereditaryIntracranialIntraspinal

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