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Culture of Bladder Cancer Organoids as Precision Medicine Tools
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Genomic classification and risk stratification of bladder cancer

Damiano Fantini1,2,3, Joshua J Meeks4,5,6,7

  • 1Department of Urology, Feinberg School of Medicine, Chicago, IL, USA.

World Journal of Urology
|November 14, 2018
PubMed

Insights

Next-generation sequencing (NGS) precisely characterizes bladder cancer molecular defects for improved classification. Precision oncology will increasingly customize bladder cancer treatment across all stages, integrating genomic data with clinical information.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Bladder cancer is a significant health concern, ranking as the fourth most common cancer in men and fifth overall.
  • Accurate molecular characterization of tumors is essential for precise classification and treatment.
  • Current applications of targeted next-generation sequencing (NGS) are primarily in metastatic bladder cancer settings.

Purpose of the Study:

  • To review genomic and transcriptomic features for bladder cancer risk stratification.
  • To summarize current precision oncology efforts in localized urothelial carcinomas.
  • To highlight the anticipated expansion of precision oncology in bladder cancer treatment.

Main Methods:

  • Review of genomic and transcriptomic data in bladder cancer.
  • Analysis of molecular defects using next-generation sequencing (NGS).
  • Integration of molecular data with clinical information like histology and TNM staging.

Main Results:

  • NGS enables precise characterization of tumor molecular defects.
  • Genomic and transcriptomic features are key for risk stratification.
  • Precision oncology approaches are evolving for bladder cancer.

Conclusions:

  • Precision oncology holds significant promise for customizing bladder cancer treatment.
  • The application of precision oncology is expected to increase across all stages of bladder cancer.
  • Further integration of molecular and clinical data will enhance bladder cancer management.
Keywords:
BiomarkerBladder cancerClassifierGenetic mutationRisk-classification

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