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Updated: May 3, 2026

Adult and Embryonic Skeletal Muscle Microexplant Culture and Isolation of Skeletal Muscle Stem Cells
Published on: September 22, 2010
Duchenne muscular dystrophy: deficiency of dystrophin at the muscle cell surface
E Bonilla1, C E Samitt, A F Miranda
1Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, New York.
Abstract:
Dystrophin is the altered gene product in Duchenne muscular dystrophy (DMD). We used polyclonal antibodies against dystrophin to immunohistochemically localize the protein in human muscle. In normal individuals and in patients with myopathies other than DMD, dystrophin was localized to the sarcolemma of the fibers. The protein was absent or markedly deficient in DMD. The sarcolemmal localization of dystrophin is consistent with other evidence that there are structural and functional abnormalities of muscle surface membranes in DMD.
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