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Updated: Feb 2, 2026

Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs
Published on: August 31, 2009
Cannabinoid dependence induces sustained changes in GABA release in the globus pallidus without affecting dopamine
Margarita Moreno1,2, Juan Decara3, Francisco Javier Pavon3
1Department of Neuroscience, The Scripps Research Institute, San Diego, CA, USA.
Abstract:
A dual probe microdialysis study was designed to characterize GABA and dopamine (DA) release in the basal ganglia of cannabinoid-dependent Wistar rats. Whereas chronic administration of the cannabinoid receptor agonist WIN55,212 (WIN) resulted in increased basal GABA release, the D2 agonist receptor-mediated control of GABA and DA release elicited by quinpirole was similar in both cannabinoid-dependent and non dependent animals. However, quinpirole did induce a greater number of more stereotypies in cannabinoid-dependent animals, indicating a dysregulated behavioral response.
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