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Updated: Feb 2, 2026

Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology
Published on: June 13, 2025
Metformin can inhibit Helicobacter pylori growth
Sarah Courtois1, Lucie Bénéjat1,2, Julien Izotte3
1INSERM, University of Bordeaux, UMR 1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, France.
Aim:
Helicobacter pylori infection is a worldwide infection, its eradication rates with conventional therapies have fallen to unacceptable levels. In this context we were interested in metformin, to determine its effect on H. pylori growth.
Materials & Methods:
Antimicrobial susceptibility tests and survival curves were performed in vitro and a H. pylori-infected mice model was used to determine metformin effect in vivo.
Results:
Helicobacter pylori survival and growth were decreased in presence of metformin. Furthermore, metformin-treated mice had significantly less bacteria in their stomach than the untreated mice.
Conclusion:
Our work is the first to demonstrate a direct antimicrobial effect of metformin on H. pylori, indicating that this molecule has not yet revealed its full potential.
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