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Association between rs12252 and influenza susceptibility and severity: an updated meta-analysis

T Chen1, M Xiao2, J Yang1

  • 1National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, P.R. China.

Epidemiology and Infection
|November 14, 2018
PubMed

Insights

The single-nucleotide polymorphism rs12252 in the IFITM3 gene is strongly associated with increased risk of both severe and mild influenza. This finding holds true across Asian and Caucasian populations, impacting influenza susceptibility.

Area of Science:

  • Genetics
  • Immunology
  • Epidemiology

Background:

  • Inconsistent findings exist regarding the association between IFITM3 single-nucleotide polymorphism (SNP, rs12252) and influenza risk.
  • Previous studies have yielded conflicting results, necessitating a comprehensive analysis.

Purpose of the Study:

  • To clarify the association between the IFITM3 rs12252 SNP and influenza risk through an updated meta-analysis.
  • To investigate the impact of this genetic variation on influenza susceptibility in different ethnic groups.

Main Methods:

  • A systematic literature search was conducted in five databases, including PubMed, up to November 9, 2017.
  • Data from ten datasets across nine studies, involving 1365 influenza patients and 5425 controls from four ethnicities, were analyzed using Revman 5.0 and Stata 12.0.
  • Four genetic models were employed to assess the SNP's association with influenza risk.

Main Results:

  • A strong association was found between the IFITM3 rs12252 SNP and influenza risk across all genetic models.
  • Significant associations were observed in Caucasians (allelic model: OR=1.35, P=0.03; homozygote model: OR=10.63, P<0.00001).
  • Novel associations were identified when comparing mild influenza patients with healthy individuals (allelic model: OR=1.37, P=0.009; dominant model: OR=1.48, P=0.01; homozygote model: OR=2.84, P=0.005).

Conclusions:

  • The T to C polymorphism in IFITM3 (rs12252) is significantly associated with an increased risk of severe and mild influenza.
  • This genetic risk factor appears relevant in both Asian and Caucasian populations.
  • The findings highlight the role of IFITM3 genetic variations in modulating influenza susceptibility.
Keywords:
Influenzameta-analysisrs12252update

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