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Interleukin (IL) -1 β, IL-6 and tumor necrosis factor in patients with seasonal flu
J M Ramos1, M García-Navarro, V Moreno
1José Manuel Ramos, Department of Internal Medicine. General University Hospital of Alicante. C/ Pintor Baeza 12, 03010 Alicante. Spain. jramosrincon@yahoo.es.
Objective:
The role of tumor necrosis factor (TNF), interleukin (IL)-1β and IL-6 in the pathogenicity of seasonal flu is unknown.
Methods:
We analyzed the profiles of these cytokines in 77 flu patients and 17 controls with non-flu respiratory infection, using molecular biology techniques (real-time polymerase chain reaction).
Results:
Flu patients had lower monocyte counts (p=0.029) and a slightly lower median level of IL-6 (P=0.05) than the control group. Twenty-four flu patients (31.2%) had pneumonia; this group had higher C-reactive proteins (p=0.01) and monocyte levels (p=0.009). Pro-inflammatory cytokines levels did not rise in patients with pneumonia complicating seasonal influenza.
Conclusions:
IL-6 levels were lower in adults with influenza.
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