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Updated: Feb 2, 2026

Chemical Dimerization-Induced Protein Condensates on Telomeres
Published on: April 12, 2021
Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
Jamshid Faraji1,2, Mitra Karimi3, Nabiollah Soltanpour4
1Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Canada.
Abstract:
The quality of social relationships is a powerful determinant of lifetime health. Here, we explored the impact of social experiences on circulating oxytocin (OT) concentration, telomere length (TL), and novelty-seeking behaviour in male and female rats. Prolonged social housing raised circulating OT levels in both sexes while elongating TL only in females. Novelty-seeking behaviour in females was more responsive to social housing and increased OT levels than males. The OT antagonist (OT ANT) L-366,509 blocked the benefits of social housing in all conditions along with female-specific TL erosion and novelty-seeking deficit. Thus, females seem more susceptible than males to genetic and behavioural changes when the secretion of endogenous OT in response to social life is interrupted. Social enrichment may, therefore, provide a therapeutic avenue to promote stress resiliency and chances of healthy aging across generations.
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