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Related Experiment Videos

Genetic amniocentesis at 14 weeks or less.

A Johnson1, L Godmilow

  • 1Jefferson Medical College, Division of Medical Genetics, Thomas Jefferson University Hospital, Philadelphia, PA 19107.

Clinical Obstetrics and Gynecology
|June 1, 1988
PubMed
Summary

Early amniocentesis (EA) is a feasible prenatal diagnostic tool, but its safety requires further investigation. While providing essential genetic information, potential risks like reduced amniotic fluid volume warrant continued study.

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Area of Science:

  • Maternal-Fetal Medicine
  • Prenatal Diagnostics
  • Genetics

Background:

  • Established methods for mid-trimester amniocentesis (MA) can be adapted for early amniocentesis (EA).
  • Amniotic fluid can be successfully obtained and cultured for diagnostic purposes.
  • Previous research suggests potential associations between mid-trimester amniocentesis and adverse pregnancy outcomes, though debated.

Purpose of the Study:

  • To evaluate the feasibility and safety of early amniocentesis (EA) for prenatal diagnosis.
  • To assess procedural and cytogenetic failure rates associated with EA.
  • To explore potential risks of EA, including effects on amniotic fluid volume and pregnancy loss.

Main Methods:

  • Review of clinical trials and existing literature on early amniocentesis.

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  • Adaptation of ultrasound-guided techniques for EA.
  • Analysis of procedural and cytogenetic failure rates from reported cases.

    • Main Results:

    • Early amniocentesis (EA) is demonstrated to be a feasible procedure.
    • Combined procedural and cytogenetic failure rates were reported as 2.0% and 0.3%, respectively.
    • Essential prenatal diagnostic information can be obtained via EA, with the exception of neural tube defect (NTD) screening before 13 weeks gestation.

    Conclusions:

    • Early amniocentesis (EA) is a viable option for prenatal diagnosis, offering necessary genetic information.
    • The safety of EA, particularly concerning potential impacts on amniotic fluid dynamics and pregnancy outcomes, remains an unanswered question.
    • Further research is needed to definitively address the safety concerns and potential complications associated with EA.