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Impaired microvascular reactivity in gestational diabetes is associated with altered glycemic parameters

Aisyah Rahman1, Seetha Munisamy1, Nor Aliza Ghaffar2

  • 1Pharmacology Vascular Laboratory, Universiti Sains Malaysia, Kota Bharu, Malaysia.

Microcirculation (New York, N.Y. : 1994)
|November 14, 2018
PubMed
Abstract

Insights

Gestational diabetes mellitus (GDM) is linked to prolonged time to peak perfusion (Tp), indicating impaired microvascular reactivity. This finding suggests potential vascular complications in GDM pregnancies.

Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Vascular Physiology

Background:

  • Gestational diabetes mellitus (GDM) affects pregnancy outcomes.
  • Microvascular dysfunction may play a role in GDM pathophysiology.
  • Assessing microvascular reactivity in GDM is crucial for understanding its impact.

Purpose of the Study:

  • To compare microvascular reactivity between women with GDM and controls.
  • To evaluate glycemic parameters in GDM pregnancies.
  • To investigate the relationship between insulin resistance and microvascular function.

Main Methods:

  • Laser Doppler Flowmetry (LDF) and post-occlusive reactive hyperemia (PORH) were used to assess microvascular reactivity.
  • Microvascular parameters including PORHmax, PORHpeak, and time to peak perfusion (Tp) were measured.
  • Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was employed to quantify insulin resistance.

Main Results:

  • Women with GDM exhibited significantly higher fasting blood glucose (FBG), 2-hour postprandial glucose, fasting insulin, and HOMA-IR compared to controls.
  • Time to peak perfusion (Tp) was significantly prolonged in the GDM group.
  • Tp showed positive correlations with FBG and 2-hour postprandial glucose levels.

Conclusions:

  • Impaired microvascular reactivity, evidenced by prolonged Tp, is present in women with GDM.
  • These findings suggest that GDM is associated with endothelial dysfunction.
  • Microvascular assessment may offer insights into the systemic effects of GDM.
Keywords:
gestational diabetesinsulin resistancelaser Doppler fluximetrymicrovascular reactivitypost-occlusive skin reactive hyperemia

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