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A "Soft" and "Hard" Ionization Method for Comprehensive Studies of Molecules
Yan Wang1, Jianghui Sun1, Jinping Qiao1
1Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry , Beijing Normal University , Beijing 100875 , China.
Analytical Chemistry
|November 14, 2018
Summary
A new spray-dependent plasma mass spectrometry (SDP MS) method bridges the gap between existing techniques for analyzing diverse molecules. This versatile ionization technique enhances molecular detection across various polarities and mass ranges.
Area of Science:
- Analytical Chemistry
- Mass Spectrometry
Background:
- Ambient mass spectrometry offers rapid molecular analysis but has limitations in detecting molecules across the full polarity spectrum.
- Existing techniques like electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) have distinct ranges, leaving a gap for certain molecular types.
Purpose of the Study:
- To establish an extensively applicable "soft" and "hard" ionization method for detecting a wide range of molecules.
- To bridge the detection gap between ESI- and APCI-based mass spectrometry techniques.
Main Methods:
- Development and application of spray-dependent plasma mass spectrometry (SDP MS).
- Utilizing SDP MS for the detection of molecules with diverse polarities and molecular weights.
Main Results:
- SDP MS successfully detected both fragment ions and intact molecular ions.
- The method effectively recorded cluster ions of aggregates in a high mass range, demonstrating softer ionization than traditional ESI MS.
- SDP MS proved effective for a broad spectrum of molecular polarities and weights.
Conclusions:
- SDP MS is a versatile ionization technique that fills the gap between ESI and APCI.
- This method enhances mass spectrometry performance for comprehensive molecular studies.
- SDP MS has broad applicability in organic synthesis, biological chemistry, medical chemistry, and clinical diagnosis.