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Donor failure after corneal transplantation surgery.
J N Buxton1, J A Seedor, H D Perry
1Department of Ophthalmology, New York Eye and Ear Infirmary, New York 10003.
Cornea
|January 1, 1988
Summary
Donor failure, characterized by early graft edema after penetrating keratoplasty, occurred in 1.2% of cases. Investigations revealed Fuchs' dystrophy, endothelial stripping, or absent keratocytes linked to eye bank storage medium pH.
Area of Science:
- Ophthalmology
- Transplantation Surgery
- Corneal Science
Background:
- Donor failure in penetrating keratoplasty presents as persistent graft edema within 24 hours.
- This condition necessitates a review of potential causes and preventative measures.
Purpose of the Study:
- To investigate the causes of early donor failure in penetrating keratoplasty.
- To identify risk factors and potential links to eye bank procedures.
Main Methods:
- Retrospective review of 1,351 penetrating keratoplasty case histories.
- Histopathological analysis of failed donor grafts.
- Evaluation of eye bank storage medium conditions.
Main Results:
- 17 cases (1.2%) exhibited donor failure.
- Identified causes included Fuchs' dystrophy (5 cases), mechanical endothelial stripping (7 cases), and absence of posterior stromal keratocytes (5 cases).
- The latter group was linked to an alkaline pH in the eye bank storage medium.
Conclusions:
- Preoperative evaluation of donor corneas is crucial.
- An "epidemic" of donor failure warrants investigation into eye bank storage methodologies, particularly pH levels.