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Rabies post-exposure prophylaxis started during or after travel: A GeoSentinel analysis.

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This summary is machine-generated.

Rabies post-exposure prophylaxis (RPEP) is often not given correctly to international travelers. Many do not receive rabies immune globulin (RIG) when indicated, with significant variation in care between countries.

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Area of Science:

  • Global Health
  • Infectious Disease Epidemiology
  • Travel Medicine

Background:

  • Rabies post-exposure prophylaxis (RPEP) is critical for preventing rabies after potential exposure.
  • Studies indicate suboptimal RPEP administration in international travelers, with low rates of rabies immune globulin (RIG) use.
  • Practices and accessibility of RIG vary significantly across different countries.

Purpose of the Study:

  • To describe the characteristics of international travelers receiving RIG and/or RPEP.
  • To identify factors influencing RIG and RPEP administration during travel.
  • To highlight country-specific variations in RPEP delivery.

Main Methods:

  • Multi-center review of international travelers exposed to potentially rabid animals.
  • Data collection on RPEP administration from GeoSentinel clinics (September 2014-July 2017).
  • Comparison of RPEP and RIG administration between travelers presenting before and at clinic presentation.

Main Results:

  • Approximately two-thirds of travelers with an indication for RIG did not receive it.
  • Travelers exposed in Indonesia were significantly less likely to receive RIG in-country.
  • Travelers exposed in Thailand, Sri Lanka, and the Philippines were more likely to receive RIG in-country.

Conclusions:

  • Significant gaps exist in the timely and appropriate delivery of RIG to international travelers.
  • Country-specific data on RIG administration are crucial for targeted traveler education.
  • Improved risk communication is needed to ensure appropriate rabies prevention for travelers.