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Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study
Manuel Delgado-Alvarado1, Rosalía Dacosta-Aguayo1,2, Irene Navalpotro-Gómez1,2
1Neurodegenerative Disorders Area, Biodonostia Health Research Institute, San Sebastián, Spain.
Background:
There is a need for biomarkers of dementia in PD.
Objectives:
To determine if the levels of the main CSF proteins and their ratios are associated with deterioration in cognition and progression to dementia in the short to mid term.
Methods:
The Parkinson's Progression Markers Initiative database was used as an exploratory cohort, and a center-based cohort was used as a replication cohort. Amyloid ß1-42, total tau, threonine-181 phosphorylated tau, and α-synuclein in the CSF and the ratios of these proteins were assessed.
Results:
In the Parkinson's Progression Markers Initiative cohort (n = 281), the total tau/amyloid ß1-42, total tau/α-synuclein, total tau/amyloid ß1-42+α-synuclein, and amyloid ß1-42/total tau ratios were associated with a risk of progression to dementia over a 3-year follow-up. In the replication cohort (n = 40), the total tau/α-synuclein and total tau/amyloid ß1-42+α-synuclein ratios were associated with progression to dementia over a 41-month follow-up.
Conclusion:
Ratios of the main proteins found in PD patient brain inclusions that can be measured in the CSF appear to have value as short- to mid-term predictors of dementia. © 2018 International Parkinson and Movement Disorder Society.