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Related Concept Videos

Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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The elemental makeup of a compound defines its chemical identity, and chemical formulas are the most concise way of representing this elemental makeup. When a compound’s formula is unknown, measuring the mass of its constituent elements is often the first step in determining the formula experimentally.
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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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An experimental design is a systematic process that allows researchers to evaluate the relationship between dependent and independent variables. There are three widely used types of experimental design - pre-experimental design, true experimental design, and quasi-experimental design. In pre-experimental design, the researcher compares the data before and after some interventions or treatments. The true-experimental design has more than one purposefully created group, a commonly measured...
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Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
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Related Experiment Video

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Basophil Activation Test for Allergy Diagnosis
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Recent Advances in Experimental Allergy.

Olivia Joan Adams1, Stephan von Gunten2

  • 1Institute of Pharmacology, University of Bern, Bern, Switzerland.

International Archives of Allergy and Immunology
|November 14, 2018
PubMed
Summary

Atopic disorders like allergies are increasing, creating a significant societal burden. This review highlights new research on treatments and molecular mechanisms for allergies, aiming to improve prevention and therapy.

Keywords:
AllergyAtopic disordersImmunomodulationInflammatory mechanisms

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Area of Science:

  • Immunology
  • Allergology
  • Molecular Medicine

Background:

  • Atopic disorders, including airway disorders, atopic dermatitis, and food allergy, are increasingly prevalent globally.
  • A deeper understanding of the underlying immunological mechanisms is crucial for developing effective treatments.
  • Current therapeutic strategies require enhancement to address the growing burden of allergic diseases.

Purpose of the Study:

  • To review recent advancements in experimental allergy research.
  • To highlight novel therapeutic alternatives for common atopic disorders.
  • To discuss molecular and cellular mechanisms relevant for future interventions.

Main Methods:

  • Literature review of recent experimental allergy studies.
  • Focus on research related to airway disorders, atopic dermatitis, and food allergy.
  • Analysis of studies investigating molecular and cellular pathways in allergy.

Main Results:

  • Identification of emerging treatment strategies for atopic conditions.
  • Elucidation of key molecular and cellular players in allergic responses.
  • Potential therapeutic targets for preventive and interventional strategies have been identified.

Conclusions:

  • Advances in experimental allergy offer promising new avenues for treatment.
  • Understanding molecular and cellular mechanisms is key to developing novel therapies.
  • Future research holds potential for improved prevention and management of atopic disorders.