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Related Concept Videos

Social Traps01:41

Social Traps

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Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
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Restriction Enzymes01:11

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Restriction enzymes are bacterial enzymes used to cut DNA in a sequence-specific manner. To cleave DNA, they bind to specific palindromic sequences called restriction sites. Such palindromic DNA sequences or inverted repeats are commonly found in regions of functional significance, such as the origin of replication, gene operator sites, and regions containing transcription termination signals.
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Impact of Individuals on Individuals01:30

Impact of Individuals on Individuals

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Human behavior is intricately shaped by social influences that arise from interactions with others in diverse contexts. These influences not only mold beliefs and attitudes but also drive the regulation of behaviors through both direct communication and observational learning. The study of these processes falls within the domain of social psychology, which seeks to understand how individuals are affected by and affect those around them.Mechanisms of Social InfluenceDirect social influence...
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Gene Flow02:39

Gene Flow

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Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
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Coronary Circulation01:21

Coronary Circulation

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The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
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Fetal Circulation01:14

Fetal Circulation

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Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
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Related Experiment Video

Updated: Feb 2, 2026

Capture and Release of Viable Circulating Tumor Cells from Blood
08:10

Capture and Release of Viable Circulating Tumor Cells from Blood

Published on: October 28, 2016

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Deterministic Capture of Individual Circulating Tumor Cells Using a Flow-Restricted Microfluidic Trap Array.

Yousang Yoon1, Jusin Lee2, Ki-Chun Yoo3

  • 1Department of Electronic Engineering, Hanyang Universtiy College of Engineering, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea. ysyoon88@hanyang.ac.kr.

Micromachines
|November 15, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a microfluidic trap array for precise separation and detection of rare circulating tumor cells (CTCs). This technology enables single-cell capture, crucial for metastasis research and automated downstream analysis.

Keywords:
circulating tumor cellmicrofluidicssingle-cell capture

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Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

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Area of Science:

  • Biomedical Engineering
  • Cancer Biology
  • Microfluidics

Background:

  • Circulating tumor cells (CTCs) are vital biomarkers but are rare, necessitating advanced separation and detection methods.
  • Accurate isolation of CTCs is critical for clinical applications and understanding metastasis.
  • Downstream analysis of individual CTCs is required to identify metastatic sub-populations.

Purpose of the Study:

  • To develop and optimize a microfluidic device for deterministic single-cell capture of circulating tumor cells.
  • To evaluate the efficiency and specificity of the microfluidic trap array for CTC isolation.
  • To demonstrate the potential of the device for both cell enumeration and future automated downstream analyses.

Main Methods:

  • Design and fabrication of a flow-restricted microfluidic trap array.
  • Optimization of flow restriction using a highly invasive breast cancer cell line (LM2 MDA-MB-231).
  • Demonstration of single-cell capture from mice with advanced metastasis.

Main Results:

  • Achieved 97% capture efficiency for circulating tumor cells.
  • Attained a 99% single-cell capture rate.
  • Successfully demonstrated single-cell capture of CTCs from metastatic mouse models.

Conclusions:

  • The flow-restricted microfluidic trap array enables precise, deterministic single-cell capture of CTCs.
  • The device offers high capture efficiency and single-cell resolution, suitable for enumeration.
  • This technology holds significant promise for future automated downstream analysis of CTCs for cancer research.