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Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications.

Madeline Small1, Addison Faglie2, Alexandra J Craig3

  • 1Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USA. msmall4@patriots.uttyler.edu.

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|November 15, 2018
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Summary
This summary is machine-generated.

Nanotechnology enables functional biomaterials with macromolecule-grafted surfaces. These advanced surfaces enhance tissue engineering and drug delivery, reducing device rejection for better biomedical applications.

Keywords:
graftingmacromoleculessurfacesthrombosiswound healing

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Surface Chemistry

Background:

  • Nanotechnology and nanomaterials have advanced functional biomaterials.
  • Surface modification of biomaterials is crucial for reducing device rejection and improving performance.
  • Macromolecule grafting creates stimuli-responsive and nanotextured surfaces.

Purpose of the Study:

  • To review the grafting of macromolecules on biomaterial surfaces.
  • To focus on nanostructure-enabled and macromolecule-grafted surfaces for biomedical applications.
  • To discuss methods for macromolecule grafting and applications in thrombosis prevention and wound healing.

Main Methods:

  • Review of literature on macromolecule grafting techniques for biomaterials.
  • Analysis of surface functionalization methods for films and fibers.
  • Discussion of stimuli-responsive and nanostructure-mimicking surface properties.

Main Results:

  • Macromolecule-grafted surfaces reduce device rejection in injectable and implantable biomaterials.
  • Functionalized surfaces improve drug release efficacy and effectiveness.
  • Hierarchical nanostructures promote cellular responses in tissue engineering.

Conclusions:

  • Nanostructure-enabled and macromolecule-grafted surfaces offer passive inhibition of adverse effects and active delivery of biological agents.
  • Surface-modified films and fibers show promise in various biomedical applications.
  • This review provides an update on current achievements and future trends in this field.