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A Plasmonic Fiber Based Glucometer and Its Temperature Dependence.

Jisoo Kim1,2, Changjin Son3, Sunjak Choi4

  • 1Department of Nano-Physics, Gachon University 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do 13120, Korea. wltndi95@naver.com.

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Summary
This summary is machine-generated.

This study introduces a novel plasmonic fiber optic sensor for glucose monitoring. The sensor demonstrates high sensitivity and stable performance across varying temperatures, offering a promising alternative to existing glucometers.

Keywords:
biosensorenzyme electrodefiber SPRglucoseoptical glucometertemperature stability

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Area of Science:

  • Biomedical Engineering
  • Optical Sensors
  • Nanotechnology

Background:

  • Accurate glucose monitoring is crucial for diabetes management.
  • Current glucose sensing technologies face limitations in sensitivity, stability, and cost.
  • Optical methods offer potential for non-invasive or minimally invasive glucose detection.

Purpose of the Study:

  • To develop and characterize a plasmonic fiber optic sensor for glucose detection.
  • To evaluate the sensor's sensitivity, precision, and temperature stability.
  • To compare the sensor's performance with commercially available glucometers.

Main Methods:

  • Fabrication of a multimode optical fiber with a gold coating for surface plasmon resonance excitation.
  • Immobilization of glucose oxidase for enzymatic glucose sensing.
  • Measurement of optical power changes in response to glucose concentration variations.
  • Assessment of sensor performance under varying ambient temperatures (-10 °C to 40 °C).

Main Results:

  • Achieved a limit of detection for glucose concentration of 6.75 mg/dL.
  • Demonstrated high sensitivity compared to wavelength-interrogating SPR glucometers.
  • Reported a coefficient of variation of 8.6% at 80 mg/dL glucose concentration at room temperature.
  • Exhibited a standard deviation of 12.1 mg/dL at 80 mg/dL glucose concentration under temperature variations, comparable to commercial devices without temperature correction.

Conclusions:

  • The plasmonic fiber optic sensor is a highly sensitive and stable platform for glucose monitoring.
  • The sensor's performance is robust across a wide range of temperatures, suggesting potential for real-world applications.
  • This technology offers a promising alternative to existing enzyme electrode-based glucometers.