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Cutaneous malakoplakia. Report of a case
1Department of Dermatology, Hospital Clínic i Provincial, Barcelona, Spain.
Dermatologica
|January 1, 1988
Summary
Cutaneous malakoplakia, a rare condition, occurred in an immunosuppressed renal transplant patient. Clofazimine successfully treated the recurrent Escherichia coli infection, leading to complete remission.
Area of Science:
- Dermatology
- Nephrology
- Microbiology
Background:
- Reports a rare case of cutaneous malakoplakia in a 44-year-old female renal transplant recipient.
- The patient was undergoing immunosuppressive therapy for nephrosclerosis.
Observation:
- A nodular lesion with inflammatory signs developed on the patient's right buttock.
- Histopathology revealed a dermal infiltrate with histiocytes containing characteristic Michaelis-Gutmann bodies.
- Electron microscopy confirmed the concentric laminar structure of Michaelis-Gutmann bodies, resembling a 'target' appearance.
Findings:
- Tissue culture identified Escherichia coli as the causative agent.
- The malakoplakia lesions recurred after surgical excision, affecting surrounding skin and the left buttock.
- Treatment with clofazimine resulted in complete remission of the recurrent lesions.
Implications:
- Highlights the importance of considering cutaneous malakoplakia in immunosuppressed patients with unusual skin lesions.
- Demonstrates the efficacy of clofazimine in treating refractory or recurrent cutaneous malakoplakia associated with Escherichia coli.
- Suggests a potential therapeutic strategy for managing this rare condition in immunocompromised individuals.